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1

Cytokine toxicity in insulin-producing cells is mediated by nitro-oxidative stress-induced hydroxyl radical formation in mitochondria

Ewa Gurgul-Convey, Ilir Mehmeti, Stephan Lortz, Sigurd Lenzen

Journal:

Journal of Molecular Medicine

Year:

2011

Language:

english

File:

PDF, 535 KB

english, 2011

2

Induction of the intrinsic apoptosis pathway in insulin-secreting cells is dependent on oxidative damage of mitochondria but independent of caspase-12 activation

Ilir Mehmeti, Ewa Gurgul-Convey, Sigurd Lenzen, Stephan Lortz

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2011

Language:

english

File:

PDF, 1003 KB

english, 2011

3

Relative importance of cellular uptake and reactive oxygen species for the toxicity of alloxan and dialuric acid to insulin-producing cells

Matthias Elsner, Ewa Gurgul-Convey, Sigurd Lenzen

Journal:

Free Radical Biology and Medicine

Year:

2006

Language:

english

File:

PDF, 429 KB

english, 2006

4

Protection of insulin-producing cells against toxicity of dexamethasone by catalase overexpression

Leticia P. Roma, Jose R. Bosqueiro, Daniel A. Cunha, Everardo M. Carneiro, Ewa Gurgul-Convey, Sigurd Lenzen, Antonio C. Boschero, Kleber L.A. Souza

Journal:

Free Radical Biology and Medicine

Year:

2009

Language:

english

File:

PDF, 714 KB

english, 2009

5

Differential effects of proinflammatory cytokines on cell death and ER stress in insulin-secreting INS1E cells and the involvement of nitric oxide

Stella Kacheva, Sigurd Lenzen, Ewa Gurgul-Convey

Journal:

Year:

2011

Language:

english

File:

PDF, 626 KB

english, 2011

6

Is there a role for neuronal nitric oxide synthase (nNOS) in cytokine toxicity to pancreatic beta cells?

Ewa Gurgul-Convey, Katarzyna Hanzelka, Sigurd Lenzen

Journal:

Year:

2012

Language:

english

File:

PDF, 850 KB

english, 2012

7

Relation Between Triketone Structure, Generation of Reactive Oxygen Species, and Selective Toxicity of the Diabetogenic Agent Alloxan

Elsner, Matthias, Gurgul-Convey, Ewa, Lenzen, Sigurd

Journal:

Antioxidants & Redox Signaling

Year:

2008

Language:

english

File:

PDF, 378 KB

english, 2008

8

Mechanism of Prostacyclin-Induced Potentiation of Glucose-Induced Insulin Secretion

Gurgul-Convey, Ewa, Hanzelka, Katarzyna, Lenzen, Sigurd

Journal:

Year:

2012

Language:

english

File:

PDF, 1.17 MB

english, 2012

9

Is Nitric Oxide Really the Primary Mediator of Pancreatic β-Cell Death in Type 1 Diabetes?

Gurgul-Convey, Ewa, Lenzen, Sigurd

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 520 KB

english, 2015

10

Physiological characterization of the human EndoC-βH1 β-cell line

Gurgul-Convey, Ewa, Kaminski, Martin T., Lenzen, Sigurd

Journal:

Biochemical and Biophysical Research Communications

Year:

2015

Language:

english

File:

PDF, 1.16 MB

english, 2015

11

Improved antioxidative defence protects insulin-producing cells against homocysteine toxicity

Scullion, Siobhan M., Hahn, Claudine, Tyka, Karolina, Flatt, Peter R., McClenaghan, Neville H., Lenzen, Sigurd, Gurgul-Convey, Ewa

Journal:

Chemico-Biological Interactions

Year:

2016

Language:

english

File:

PDF, 1.89 MB

english, 2016

12

Sensitivity profile of the human EndoC-βH1 beta cell line to proinflammatory cytokines

Gurgul-Convey, Ewa, Mehmeti, Ilir, Plötz, Thomas, Jörns, Anne, Lenzen, Sigurd

Journal:

Year:

2016

Language:

english

File:

PDF, 4.34 MB

english, 2016

13

Overexpression of sphingosine-1 phosphate lyase protects insulin-secreting cells against cytokine toxicity

Hahn, Claudine, Tyka, Karolina, Saba, Julie D., Lenzen, Sigurd, Gurgul-Convey, Ewa

Journal:

Journal of Biological Chemistry

Year:

2017

Language:

english

File:

PDF, 856 KB

english, 2017

14

MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity

Tyka, Karolina, Jörns, Anne, Turatsinze, Jean-Valery, Eizirik, Decio L., Lenzen, Sigurd, Gurgul-Convey, Ewa

Journal:

Cell Death and Disease

Year:

2019

Language:

english

File:

PDF, 3.48 MB

english, 2019

15

Sphingolipids in Type 1 Diabetes: Focus on Beta-Cells

Gurgul-Convey, Ewa

Journal:

Year:

2020

File:

PDF, 1.68 MB

2020

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